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3D Bioplotter Research Papers
Displaying all papers by M. Rana (1 results)
Accelerating the early angiogenesis of tissue engineering constructs in vivo by the use of stem cells cultured in matrigel
Journal of Biomedical Materials Research Part A
2014
Volume 102, Issue 6, Pages 1652–1662
In tissue engineering research, generating constructs with an adequate extent of clinical applications remains a major challenge. In this context, rapid blood vessel ingrowth in the transplanted tissue engineering constructs is the key factor for successful incorporation. To accelerate the microvascular development in engineered tissues, we preincubated osteoblast-like cells as well as mesenchymal stem cells or a combination of both cell types in Matrigel-filled PLGA scaffolds before transplantation into the dorsal skinfold chambers of balb/c mice. By the use of preincubated mesenchymal stem cells, a significantly accelerated angiogenesis was achieved. Compared with previous studies that showed a decisive increase of…